| School | 21-22 Class | 21-22 District | 20-21 Class | Up or Down? |
| Bishop DuBourg High School | 1 | 1 | 1 | Same |
| Brentwood High School | 1 | 1 | 1 | Same |
| Central (New Madrid County) High School | 1 | 1 | 1 | Same |
| Fatima High School | 1 | 1 | 1 | Same |
| Gateway Science Academy Charter High School | 1 | 1 | No 20-21 Class | No 20-21 Class |
| Hancock High School | 1 | 1 | 2 | Down |
| John Burroughs High School | 1 | 1 | No 20-21 Class | No 20-21 Class |
| Lift for Life Academy Charter High School | 1 | 1 | 1 | Same |
| Maplewood-Richmond Hts. High School | 1 | 1 | No 20-21 Class | No 20-21 Class |
| North Callaway High School | 1 | 1 | 1 | Same |
| Notre Dame (Cape Girardeau) High School | 1 | 1 | 2 | Down |
| South Callaway High School | 1 | 1 | 1 | Same |
| St. Francis Borgia High School | 1 | 1 | 2 | Down |
| St. Pius X (Festus) High School | 1 | 1 | No 20-21 Class | No 20-21 Class |
| STEAM Academy at McCluer South-Berkeley High School | 1 | 1 | No 20-21 Class | No 20-21 Class |
| Valle Catholic High School | 1 | 1 | 1 | Same |
| Adrian High School | 1 | 2 | 1 | Same |
| Butler High School | 1 | 2 | 1 | Same |
| California High School | 1 | 2 | 1 | Same |
| Cole Camp High School | 1 | 2 | No 20-21 Class | No 20-21 Class |
| Diamond High School | 1 | 2 | 1 | Same |
| El Dorado Springs High School | 1 | 2 | 1 | Same |
| Father Tolton Regional Catholic High School | 1 | 2 | 1 | Same |
| Holden High School | 1 | 2 | 1 | Same |
| Knob Noster High School | 1 | 2 | 1 | Same |
| Lone Jack High School | 1 | 2 | 1 | Same |
| Sherwood High School | 1 | 2 | 1 | Same |
| St. Michael the Archangel Catholic High School | 1 | 2 | 1 | Same |
| Summit Christian Academy High School | 1 | 2 | 1 | Same |
| Tipton High School | 1 | 2 | 1 | Same |
| Versailles High School | 1 | 2 | 1 | Same |
| Warsaw High School | 1 | 2 | 1 | Same |
| Brookfield High School | 1 | 3 | 1 | Same |
| Carrollton High School | 1 | 3 | 1 | Same |
| Centralia High School | 1 | 3 | 1 | Same |
| Gallatin High School | 1 | 3 | 1 | Same |
| Lafayette County High School | 1 | 3 | 1 | Same |
| Lexington High School | 1 | 3 | 1 | Same |
| Marceline High School | 1 | 3 | 1 | Same |
| Missouri Military Academy High School | 1 | 3 | 1 | Same |
| Palmyra High School | 1 | 3 | 1 | Same |
| Penney High School | 1 | 3 | 1 | Same |
| Polo High School | 1 | 3 | 1 | Same |
| Richmond High School | 1 | 3 | 1 | Same |
| South Harrison High School | 1 | 3 | 1 | Same |
| St. Paul Lutheran (Concordia) High School | 1 | 3 | 1 | Same |
| Trenton High School | 1 | 3 | 1 | Same |
| Albany High School | 1 | 4 | 1 | Same |
| Lathrop High School | 1 | 4 | 1 | Same |
| Lawson High School | 1 | 4 | 1 | Same |
| Maysville High School | 1 | 4 | 1 | Same |
| Mid-Buchanan High School | 1 | 4 | 1 | Same |
| North Andrew High School | 1 | 4 | 1 | Same |
| Pembroke Hill High School | 1 | 4 | No 20-21 Class | No 20-21 Class |
| Plattsburg High School | 1 | 4 | 1 | Same |
| Rock Port High School | 1 | 4 | 1 | Same |
| St. Pius X (Kansas City) High School | 1 | 4 | 1 | Same |
| Stanberry High School | 1 | 4 | 1 | Same |
| Tarkio High School | 1 | 4 | 1 | Same |
| University Academy Charter High School | 1 | 4 | 1 | Same |
| West Platte High School | 1 | 4 | 1 | Same |
| Affton High School | 2 | 1 | 2 | Same |
| Central (Park Hills) High School | 2 | 1 | 2 | Same |
| Dexter High School | 2 | 1 | 2 | Same |
| Herculaneum High School | 2 | 1 | 2 | Same |
| Kennett High School | 2 | 1 | 2 | Same |
| MICDS High School | 2 | 1 | No 20-21 Class | No 20-21 Class |
| Normandy Collaborative High School | 2 | 1 | No 20-21 Class | No 20-21 Class |
| Owensville High School | 2 | 1 | 2 | Same |
| Potosi High School | 2 | 1 | 2 | Same |
| St. Clair High School | 2 | 1 | 2 | Same |
| St. James High School | 2 | 1 | 2 | Same |
| St. Mary’s (St. Louis) High School | 2 | 1 | 2 | Same |
| Ste. Genevieve High School | 2 | 1 | 2 | Same |
| Sullivan High School | 2 | 1 | 2 | Same |
| University City High School | 2 | 1 | 2 | Same |
| Boonville High School | 2 | 2 | 2 | Same |
| Fulton High School | 2 | 2 | 2 | Same |
| Hallsville High School | 2 | 2 | 1 | Up |
| Kirksville High School | 2 | 2 | 2 | Same |
| Lutheran St. Charles High School | 2 | 2 | 2 | Same |
| Macon High School | 2 | 2 | 1 | Up |
| Mexico High School | 2 | 2 | 2 | Same |
| Moberly High School | 2 | 2 | 2 | Same |
| Orchard Farm High School | 2 | 2 | 2 | Same |
| Priory High School | 2 | 2 | 2 | Same |
| Southern Boone High School | 2 | 2 | 2 | Same |
| St. Charles High School | 2 | 2 | 2 | Same |
| St. Charles West High School | 2 | 2 | 2 | Same |
| Westminster Christian Academy High School | 2 | 2 | 2 | Same |
| Winfield High School | 2 | 2 | 2 | Same |
| Wright City High School | 2 | 2 | 2 | Same |
| Aurora High School | 2 | 3 | No 20-21 Class | No 20-21 Class |
| Blair Oaks High School | 2 | 3 | 2 | Same |
| Buffalo High School | 2 | 3 | 2 | Same |
| Cassville High School | 2 | 3 | 2 | Same |
| Clinton High School | 2 | 3 | 2 | Same |
| Eldon High School | 2 | 3 | 2 | Same |
| Harrisonville High School | 2 | 3 | 2 | Same |
| Helias Catholic High School | 2 | 3 | 2 | Same |
| Hollister High School | 2 | 3 | 2 | Same |
| Logan-Rogersville High School | 2 | 3 | 2 | Same |
| Monett High School | 2 | 3 | 2 | Same |
| Nevada High School | 2 | 3 | 2 | Same |
| Osage High School | 2 | 3 | 2 | Same |
| Reeds Spring High School | 2 | 3 | 2 | Same |
| Seneca High School | 2 | 3 | 2 | Same |
| Benton High School | 2 | 4 | 2 | Same |
| Cameron High School | 2 | 4 | 2 | Same |
| Center High School | 2 | 4 | 2 | Same |
| Central (Kansas City) High School | 2 | 4 | No 20-21 Class | No 20-21 Class |
| Chillicothe High School | 2 | 4 | 2 | Same |
| Excelsior Springs High School | 2 | 4 | 2 | Same |
| Lafayette (St. Joseph) High School | 2 | 4 | 2 | Same |
| Marshall High School | 2 | 4 | 2 | Same |
| Maryville High School | 2 | 4 | 2 | Same |
| Northeast (Kansas City) High School | 2 | 4 | No 20-21 Class | No 20-21 Class |
| Oak Grove High School | 2 | 4 | 2 | Same |
| Odessa High School | 2 | 4 | 2 | Same |
| Pleasant Hill High School | 2 | 4 | 2 | Same |
| Savannah High School | 2 | 4 | 2 | Same |
| Southeast High School | 2 | 4 | No 20-21 Class | No 20-21 Class |
| Central (Cape Girardeau) High School | 3 | 1 | 3 | Same |
| DeSoto High School | 3 | 1 | 3 | Same |
| Farmington High School | 3 | 1 | 3 | Same |
| Festus High School | 3 | 1 | 3 | Same |
| Gateway High School | 3 | 1 | No 20-21 Class | No 20-21 Class |
| Hillsboro High School | 3 | 1 | 3 | Same |
| Mehlville High School | 3 | 1 | 3 | Same |
| North County High School | 3 | 1 | 3 | Same |
| Pacific High School | 3 | 1 | 3 | Same |
| Rockwood Summit High School | 3 | 1 | 3 | Same |
| Roosevelt High School | 3 | 1 | No 20-21 Class | No 20-21 Class |
| Sikeston High School | 3 | 1 | 3 | Same |
| Vianney High School | 3 | 1 | 3 | Same |
| Washington High School | 3 | 1 | 4 | Down |
| Webster Groves High School | 3 | 1 | 3 | Same |
| Windsor (Imperial) High School | 3 | 1 | 3 | Same |
| Chaminade College Preparatory High School | 3 | 2 | 3 | Same |
| Clayton High School | 3 | 2 | 3 | Same |
| DeSmet High School | 3 | 2 | 3 | Same |
| Ft. Zumwalt East High School | 3 | 2 | 3 | Same |
| Hazelwood East High School | 3 | 2 | 3 | Same |
| Ladue Horton Watkins High School | 3 | 2 | 3 | Same |
| McCluer High School | 3 | 2 | No 20-21 Class | No 20-21 Class |
| McCluer North High School | 3 | 2 | 3 | Same |
| North Point High School | 3 | 2 | No 20-21 Class | No 20-21 Class |
| Parkway Central High School | 3 | 2 | 3 | Same |
| Parkway North High School | 3 | 2 | 3 | Same |
| Parkway West High School | 3 | 2 | 3 | Same |
| Vashon High School | 3 | 2 | No 20-21 Class | No 20-21 Class |
| Warrenton High School | 3 | 2 | 3 | Same |
| Whitfield High School | 3 | 2 | 3 | Same |
| Bolivar High School | 3 | 3 | 3 | Same |
| Branson High School | 3 | 3 | 3 | Same |
| Camdenton High School | 3 | 3 | 3 | Same |
| Carl Junction High School | 3 | 3 | 3 | Same |
| Glendale High School | 3 | 3 | 3 | Same |
| Hillcrest High School | 3 | 3 | 3 | Same |
| Marshfield High School | 3 | 3 | 3 | Same |
| McDonald County High School | 3 | 3 | 3 | Same |
| Neosho High School | 3 | 3 | 3 | Same |
| Parkview High School | 3 | 3 | 3 | Same |
| Rolla High School | 3 | 3 | 3 | Same |
| Union High School | 3 | 3 | 3 | Same |
| Webb City High School | 3 | 3 | 3 | Same |
| West Plains High School | 3 | 3 | 3 | Same |
| Willard High School | 3 | 3 | 3 | Same |
| Capital City High School | 3 | 4 | 4 | Down |
| East (Kansas City) High School | 3 | 4 | No 20-21 Class | No 20-21 Class |
| Grandview High School | 3 | 4 | 3 | Same |
| Hannibal High School | 3 | 4 | 3 | Same |
| Jefferson City High School | 3 | 4 | 4 | Down |
| Kearney High School | 3 | 4 | 3 | Same |
| Lincoln College Prep High School | 3 | 4 | No 20-21 Class | No 20-21 Class |
| Platte County High School | 3 | 4 | 3 | Same |
| Raytown South High School | 3 | 4 | 3 | Same |
| Ruskin High School | 3 | 4 | 3 | Same |
| Smithville High School | 3 | 4 | 3 | Same |
| Van Horn High School | 3 | 4 | 3 | Same |
| Warrensburg High School | 3 | 4 | 3 | Same |
| William Chrisman High School | 3 | 4 | 3 | Same |
| Winnetonka High School | 3 | 4 | 3 | Same |
| Christian Brothers College High School | 4 | 1 | 4 | Same |
| Eureka High School | 4 | 1 | 4 | Same |
| Fox High School | 4 | 1 | 4 | Same |
| Jackson High School | 4 | 1 | 4 | Same |
| Kirkwood High School | 4 | 1 | 4 | Same |
| Lafayette (Wildwood) High School | 4 | 1 | 4 | Same |
| Lindbergh High School | 4 | 1 | 4 | Same |
| Marquette High School | 4 | 1 | 4 | Same |
| Northwest (Cedar Hill) High School | 4 | 1 | 4 | Same |
| Oakville High School | 4 | 1 | 4 | Same |
| Parkway South High School | 4 | 1 | 4 | Same |
| Poplar Bluff High School | 4 | 1 | 4 | Same |
| Ritenour High School | 4 | 1 | 4 | Same |
| Seckman High School | 4 | 1 | 4 | Same |
| St. Louis University High School | 4 | 1 | 4 | Same |
| Battle High School | 4 | 2 | 4 | Same |
| Francis Howell High School | 4 | 2 | 4 | Same |
| Francis Howell Central High School | 4 | 2 | 4 | Same |
| Francis Howell North High School | 4 | 2 | 4 | Same |
| Ft. Zumwalt North High School | 4 | 2 | 4 | Same |
| Ft. Zumwalt South High School | 4 | 2 | 3 | Up |
| Ft. Zumwalt West High School | 4 | 2 | 4 | Same |
| Hazelwood Central High School | 4 | 2 | No 20-21 Class | No 20-21 Class |
| Hazelwood West High School | 4 | 2 | 4 | Same |
| Hickman High School | 4 | 2 | 4 | Same |
| Holt High School | 4 | 2 | 4 | Same |
| Liberty (Wentzville) High School | 4 | 2 | 3 | Up |
| Pattonville High School | 4 | 2 | 4 | Same |
| Rock Bridge High School | 4 | 2 | 4 | Same |
| Timberland High School | 4 | 2 | 4 | Same |
| Troy Buchanan High School | 4 | 2 | 4 | Same |
| Belton High School | 4 | 3 | 3 | Up |
| Carthage High School | 4 | 3 | 4 | Same |
| Central (Springfield) High School | 4 | 3 | 4 | Same |
| Joplin High School | 4 | 3 | 4 | Same |
| Kickapoo High School | 4 | 3 | 4 | Same |
| Lebanon High School | 4 | 3 | 3 | Up |
| Lee’s Summit High School | 4 | 3 | 4 | Same |
| Lee’s Summit North High School | 4 | 3 | 4 | Same |
| Lee’s Summit West High School | 4 | 3 | 4 | Same |
| Nixa High School | 4 | 3 | 4 | Same |
| Ozark High School | 4 | 3 | 4 | Same |
| Raymore-Peculiar High School | 4 | 3 | 4 | Same |
| Republic High School | 4 | 3 | 4 | Same |
| Smith-Cotton High School | 4 | 3 | 4 | Same |
| Waynesville High School | 4 | 3 | 4 | Same |
| Blue Springs High School | 4 | 4 | 4 | Same |
| Blue Springs South High School | 4 | 4 | 4 | Same |
| Central (St. Joseph) High School | 4 | 4 | 4 | Same |
| Fort Osage High School | 4 | 4 | 3 | Up |
| Grain Valley High School | 4 | 4 | 3 | Up |
| Liberty High School | 4 | 4 | 4 | Same |
| Liberty North High School | 4 | 4 | 4 | Same |
| North Kansas City High School | 4 | 4 | 4 | Same |
| Oak Park High School | 4 | 4 | 4 | Same |
| Park Hill High School | 4 | 4 | 4 | Same |
| Park Hill South High School | 4 | 4 | 4 | Same |
| Raytown High School | 4 | 4 | 4 | Same |
| Rockhurst High School | 4 | 4 | 4 | Same |
| Staley High School | 4 | 4 | 4 | Same |
| Truman High School | 4 | 4 | 4 | Same |