| School | 21-22 Class | 21-22 District | 20-21 Class | Up or Down? | 
| Bishop DuBourg High School | 1 | 1 | 1 | Same | 
| Brentwood High School | 1 | 1 | 1 | Same | 
| Central (New Madrid County) High School | 1 | 1 | 1 | Same | 
| Fatima High School | 1 | 1 | 1 | Same | 
| Gateway Science Academy Charter High School | 1 | 1 | No 20-21 Class | No 20-21 Class | 
| Hancock High School | 1 | 1 | 2 | Down | 
| John Burroughs High School | 1 | 1 | No 20-21 Class | No 20-21 Class | 
| Lift for Life Academy Charter High School | 1 | 1 | 1 | Same | 
| Maplewood-Richmond Hts. High School | 1 | 1 | No 20-21 Class | No 20-21 Class | 
| North Callaway High School | 1 | 1 | 1 | Same | 
| Notre Dame (Cape Girardeau) High School | 1 | 1 | 2 | Down | 
| South Callaway High School | 1 | 1 | 1 | Same | 
| St. Francis Borgia High School | 1 | 1 | 2 | Down | 
| St. Pius X (Festus) High School | 1 | 1 | No 20-21 Class | No 20-21 Class | 
| STEAM Academy at McCluer South-Berkeley High School | 1 | 1 | No 20-21 Class | No 20-21 Class | 
| Valle Catholic High School | 1 | 1 | 1 | Same | 
| Adrian High School | 1 | 2 | 1 | Same | 
| Butler High School | 1 | 2 | 1 | Same | 
| California High School | 1 | 2 | 1 | Same | 
| Cole Camp High School | 1 | 2 | No 20-21 Class | No 20-21 Class | 
| Diamond High School | 1 | 2 | 1 | Same | 
| El Dorado Springs High School | 1 | 2 | 1 | Same | 
| Father Tolton Regional Catholic High School | 1 | 2 | 1 | Same | 
| Holden High School | 1 | 2 | 1 | Same | 
| Knob Noster High School | 1 | 2 | 1 | Same | 
| Lone Jack High School | 1 | 2 | 1 | Same | 
| Sherwood High School | 1 | 2 | 1 | Same | 
| St. Michael the Archangel Catholic High School | 1 | 2 | 1 | Same | 
| Summit Christian Academy High School | 1 | 2 | 1 | Same | 
| Tipton High School | 1 | 2 | 1 | Same | 
| Versailles High School | 1 | 2 | 1 | Same | 
| Warsaw High School | 1 | 2 | 1 | Same | 
| Brookfield High School | 1 | 3 | 1 | Same | 
| Carrollton High School | 1 | 3 | 1 | Same | 
| Centralia High School | 1 | 3 | 1 | Same | 
| Gallatin High School | 1 | 3 | 1 | Same | 
| Lafayette County High School | 1 | 3 | 1 | Same | 
| Lexington High School | 1 | 3 | 1 | Same | 
| Marceline High School | 1 | 3 | 1 | Same | 
| Missouri Military Academy High School | 1 | 3 | 1 | Same | 
| Palmyra High School | 1 | 3 | 1 | Same | 
| Penney High School | 1 | 3 | 1 | Same | 
| Polo High School | 1 | 3 | 1 | Same | 
| Richmond High School | 1 | 3 | 1 | Same | 
| South Harrison High School | 1 | 3 | 1 | Same | 
| St. Paul Lutheran (Concordia) High School | 1 | 3 | 1 | Same | 
| Trenton High School | 1 | 3 | 1 | Same | 
| Albany High School | 1 | 4 | 1 | Same | 
| Lathrop High School | 1 | 4 | 1 | Same | 
| Lawson High School | 1 | 4 | 1 | Same | 
| Maysville High School | 1 | 4 | 1 | Same | 
| Mid-Buchanan High School | 1 | 4 | 1 | Same | 
| North Andrew High School | 1 | 4 | 1 | Same | 
| Pembroke Hill High School | 1 | 4 | No 20-21 Class | No 20-21 Class | 
| Plattsburg High School | 1 | 4 | 1 | Same | 
| Rock Port High School | 1 | 4 | 1 | Same | 
| St. Pius X (Kansas City) High School | 1 | 4 | 1 | Same | 
| Stanberry High School | 1 | 4 | 1 | Same | 
| Tarkio High School | 1 | 4 | 1 | Same | 
| University Academy Charter High School | 1 | 4 | 1 | Same | 
| West Platte High School | 1 | 4 | 1 | Same | 
| Affton High School | 2 | 1 | 2 | Same | 
| Central (Park Hills) High School | 2 | 1 | 2 | Same | 
| Dexter High School | 2 | 1 | 2 | Same | 
| Herculaneum High School | 2 | 1 | 2 | Same | 
| Kennett High School | 2 | 1 | 2 | Same | 
| MICDS High School | 2 | 1 | No 20-21 Class | No 20-21 Class | 
| Normandy Collaborative High School | 2 | 1 | No 20-21 Class | No 20-21 Class | 
| Owensville High School | 2 | 1 | 2 | Same | 
| Potosi High School | 2 | 1 | 2 | Same | 
| St. Clair High School | 2 | 1 | 2 | Same | 
| St. James High School | 2 | 1 | 2 | Same | 
| St. Mary’s (St. Louis) High School | 2 | 1 | 2 | Same | 
| Ste. Genevieve High School | 2 | 1 | 2 | Same | 
| Sullivan High School | 2 | 1 | 2 | Same | 
| University City High School | 2 | 1 | 2 | Same | 
| Boonville High School | 2 | 2 | 2 | Same | 
| Fulton High School | 2 | 2 | 2 | Same | 
| Hallsville High School | 2 | 2 | 1 | Up | 
| Kirksville High School | 2 | 2 | 2 | Same | 
| Lutheran St. Charles High School | 2 | 2 | 2 | Same | 
| Macon High School | 2 | 2 | 1 | Up | 
| Mexico High School | 2 | 2 | 2 | Same | 
| Moberly High School | 2 | 2 | 2 | Same | 
| Orchard Farm High School | 2 | 2 | 2 | Same | 
| Priory High School | 2 | 2 | 2 | Same | 
| Southern Boone High School | 2 | 2 | 2 | Same | 
| St. Charles High School | 2 | 2 | 2 | Same | 
| St. Charles West High School | 2 | 2 | 2 | Same | 
| Westminster Christian Academy High School | 2 | 2 | 2 | Same | 
| Winfield High School | 2 | 2 | 2 | Same | 
| Wright City High School | 2 | 2 | 2 | Same | 
| Aurora High School | 2 | 3 | No 20-21 Class | No 20-21 Class | 
| Blair Oaks High School | 2 | 3 | 2 | Same | 
| Buffalo High School | 2 | 3 | 2 | Same | 
| Cassville High School | 2 | 3 | 2 | Same | 
| Clinton High School | 2 | 3 | 2 | Same | 
| Eldon High School | 2 | 3 | 2 | Same | 
| Harrisonville High School | 2 | 3 | 2 | Same | 
| Helias Catholic High School | 2 | 3 | 2 | Same | 
| Hollister High School | 2 | 3 | 2 | Same | 
| Logan-Rogersville High School | 2 | 3 | 2 | Same | 
| Monett High School | 2 | 3 | 2 | Same | 
| Nevada High School | 2 | 3 | 2 | Same | 
| Osage High School | 2 | 3 | 2 | Same | 
| Reeds Spring High School | 2 | 3 | 2 | Same | 
| Seneca High School | 2 | 3 | 2 | Same | 
| Benton High School | 2 | 4 | 2 | Same | 
| Cameron High School | 2 | 4 | 2 | Same | 
| Center High School | 2 | 4 | 2 | Same | 
| Central (Kansas City) High School | 2 | 4 | No 20-21 Class | No 20-21 Class | 
| Chillicothe High School | 2 | 4 | 2 | Same | 
| Excelsior Springs High School | 2 | 4 | 2 | Same | 
| Lafayette (St. Joseph) High School | 2 | 4 | 2 | Same | 
| Marshall High School | 2 | 4 | 2 | Same | 
| Maryville High School | 2 | 4 | 2 | Same | 
| Northeast (Kansas City) High School | 2 | 4 | No 20-21 Class | No 20-21 Class | 
| Oak Grove High School | 2 | 4 | 2 | Same | 
| Odessa High School | 2 | 4 | 2 | Same | 
| Pleasant Hill High School | 2 | 4 | 2 | Same | 
| Savannah High School | 2 | 4 | 2 | Same | 
| Southeast High School | 2 | 4 | No 20-21 Class | No 20-21 Class | 
| Central (Cape Girardeau) High School | 3 | 1 | 3 | Same | 
| DeSoto High School | 3 | 1 | 3 | Same | 
| Farmington High School | 3 | 1 | 3 | Same | 
| Festus High School | 3 | 1 | 3 | Same | 
| Gateway High School | 3 | 1 | No 20-21 Class | No 20-21 Class | 
| Hillsboro High School | 3 | 1 | 3 | Same | 
| Mehlville High School | 3 | 1 | 3 | Same | 
| North County High School | 3 | 1 | 3 | Same | 
| Pacific High School | 3 | 1 | 3 | Same | 
| Rockwood Summit High School | 3 | 1 | 3 | Same | 
| Roosevelt High School | 3 | 1 | No 20-21 Class | No 20-21 Class | 
| Sikeston High School | 3 | 1 | 3 | Same | 
| Vianney High School | 3 | 1 | 3 | Same | 
| Washington High School | 3 | 1 | 4 | Down | 
| Webster Groves High School | 3 | 1 | 3 | Same | 
| Windsor (Imperial) High School | 3 | 1 | 3 | Same | 
| Chaminade College Preparatory High School | 3 | 2 | 3 | Same | 
| Clayton High School | 3 | 2 | 3 | Same | 
| DeSmet High School | 3 | 2 | 3 | Same | 
| Ft. Zumwalt East High School | 3 | 2 | 3 | Same | 
| Hazelwood East High School | 3 | 2 | 3 | Same | 
| Ladue Horton Watkins High School | 3 | 2 | 3 | Same | 
| McCluer High School | 3 | 2 | No 20-21 Class | No 20-21 Class | 
| McCluer North High School | 3 | 2 | 3 | Same | 
| North Point High School | 3 | 2 | No 20-21 Class | No 20-21 Class | 
| Parkway Central High School | 3 | 2 | 3 | Same | 
| Parkway North High School | 3 | 2 | 3 | Same | 
| Parkway West High School | 3 | 2 | 3 | Same | 
| Vashon High School | 3 | 2 | No 20-21 Class | No 20-21 Class | 
| Warrenton High School | 3 | 2 | 3 | Same | 
| Whitfield High School | 3 | 2 | 3 | Same | 
| Bolivar High School | 3 | 3 | 3 | Same | 
| Branson High School | 3 | 3 | 3 | Same | 
| Camdenton High School | 3 | 3 | 3 | Same | 
| Carl Junction High School | 3 | 3 | 3 | Same | 
| Glendale High School | 3 | 3 | 3 | Same | 
| Hillcrest High School | 3 | 3 | 3 | Same | 
| Marshfield High School | 3 | 3 | 3 | Same | 
| McDonald County High School | 3 | 3 | 3 | Same | 
| Neosho High School | 3 | 3 | 3 | Same | 
| Parkview High School | 3 | 3 | 3 | Same | 
| Rolla High School | 3 | 3 | 3 | Same | 
| Union High School | 3 | 3 | 3 | Same | 
| Webb City High School | 3 | 3 | 3 | Same | 
| West Plains High School | 3 | 3 | 3 | Same | 
| Willard High School | 3 | 3 | 3 | Same | 
| Capital City High School | 3 | 4 | 4 | Down | 
| East (Kansas City) High School | 3 | 4 | No 20-21 Class | No 20-21 Class | 
| Grandview High School | 3 | 4 | 3 | Same | 
| Hannibal High School | 3 | 4 | 3 | Same | 
| Jefferson City High School | 3 | 4 | 4 | Down | 
| Kearney High School | 3 | 4 | 3 | Same | 
| Lincoln College Prep High School | 3 | 4 | No 20-21 Class | No 20-21 Class | 
| Platte County High School | 3 | 4 | 3 | Same | 
| Raytown South High School | 3 | 4 | 3 | Same | 
| Ruskin High School | 3 | 4 | 3 | Same | 
| Smithville High School | 3 | 4 | 3 | Same | 
| Van Horn High School | 3 | 4 | 3 | Same | 
| Warrensburg High School | 3 | 4 | 3 | Same | 
| William Chrisman High School | 3 | 4 | 3 | Same | 
| Winnetonka High School | 3 | 4 | 3 | Same | 
| Christian Brothers College High School | 4 | 1 | 4 | Same | 
| Eureka High School | 4 | 1 | 4 | Same | 
| Fox High School | 4 | 1 | 4 | Same | 
| Jackson High School | 4 | 1 | 4 | Same | 
| Kirkwood High School | 4 | 1 | 4 | Same | 
| Lafayette (Wildwood) High School | 4 | 1 | 4 | Same | 
| Lindbergh High School | 4 | 1 | 4 | Same | 
| Marquette High School | 4 | 1 | 4 | Same | 
| Northwest (Cedar Hill) High School | 4 | 1 | 4 | Same | 
| Oakville High School | 4 | 1 | 4 | Same | 
| Parkway South High School | 4 | 1 | 4 | Same | 
| Poplar Bluff High School | 4 | 1 | 4 | Same | 
| Ritenour High School | 4 | 1 | 4 | Same | 
| Seckman High School | 4 | 1 | 4 | Same | 
| St. Louis University High School | 4 | 1 | 4 | Same | 
| Battle High School | 4 | 2 | 4 | Same | 
| Francis Howell High School | 4 | 2 | 4 | Same | 
| Francis Howell Central High School | 4 | 2 | 4 | Same | 
| Francis Howell North High School | 4 | 2 | 4 | Same | 
| Ft. Zumwalt North High School | 4 | 2 | 4 | Same | 
| Ft. Zumwalt South High School | 4 | 2 | 3 | Up | 
| Ft. Zumwalt West High School | 4 | 2 | 4 | Same | 
| Hazelwood Central High School | 4 | 2 | No 20-21 Class | No 20-21 Class | 
| Hazelwood West High School | 4 | 2 | 4 | Same | 
| Hickman High School | 4 | 2 | 4 | Same | 
| Holt High School | 4 | 2 | 4 | Same | 
| Liberty (Wentzville) High School | 4 | 2 | 3 | Up | 
| Pattonville High School | 4 | 2 | 4 | Same | 
| Rock Bridge High School | 4 | 2 | 4 | Same | 
| Timberland High School | 4 | 2 | 4 | Same | 
| Troy Buchanan High School | 4 | 2 | 4 | Same | 
| Belton High School | 4 | 3 | 3 | Up | 
| Carthage High School | 4 | 3 | 4 | Same | 
| Central (Springfield) High School | 4 | 3 | 4 | Same | 
| Joplin High School | 4 | 3 | 4 | Same | 
| Kickapoo High School | 4 | 3 | 4 | Same | 
| Lebanon High School | 4 | 3 | 3 | Up | 
| Lee’s Summit High School | 4 | 3 | 4 | Same | 
| Lee’s Summit North High School | 4 | 3 | 4 | Same | 
| Lee’s Summit West High School | 4 | 3 | 4 | Same | 
| Nixa High School | 4 | 3 | 4 | Same | 
| Ozark High School | 4 | 3 | 4 | Same | 
| Raymore-Peculiar High School | 4 | 3 | 4 | Same | 
| Republic High School | 4 | 3 | 4 | Same | 
| Smith-Cotton High School | 4 | 3 | 4 | Same | 
| Waynesville High School | 4 | 3 | 4 | Same | 
| Blue Springs High School | 4 | 4 | 4 | Same | 
| Blue Springs South High School | 4 | 4 | 4 | Same | 
| Central (St. Joseph) High School | 4 | 4 | 4 | Same | 
| Fort Osage High School | 4 | 4 | 3 | Up | 
| Grain Valley High School | 4 | 4 | 3 | Up | 
| Liberty High School | 4 | 4 | 4 | Same | 
| Liberty North High School | 4 | 4 | 4 | Same | 
| North Kansas City High School | 4 | 4 | 4 | Same | 
| Oak Park High School | 4 | 4 | 4 | Same | 
| Park Hill High School | 4 | 4 | 4 | Same | 
| Park Hill South High School | 4 | 4 | 4 | Same | 
| Raytown High School | 4 | 4 | 4 | Same | 
| Rockhurst High School | 4 | 4 | 4 | Same | 
| Staley High School | 4 | 4 | 4 | Same | 
| Truman High School | 4 | 4 | 4 | Same |